Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.

doi:10.1186/1471-230X-10-112

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Article

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.

BMC gastroenterology - 28 Sept 2010

Campa Daniele, Pardini Barbara, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Steinke Verena, Rahner Nils, Holinski-Feder Elke, Morak Monika, Schackert Hans K, Görgens Heike, Kötting Judith, Betz Beate, Kloor Matthias, Engel Christoph, Büttner Reinhard, Propping Peter, Försti Asta, Hemminki Kari, Barale Roberto, Vodicka Pavel, Canzian Federico

Abstract excerpt

BACKGROUND: Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. METHODS: We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin...

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PMID: 20920174
DOI: 10.1186/1471-230X-10-112
PMCID: PMC2954942

Genes

GHSR
GHRL

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