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Article

RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis.

Nature - 1 Oct 2024

Zou Zhongyu, Dou Xiaoyang, Li Ying, Zhang Zijie, Wang Juan, Gao Boyang, Xiao Yu, Wang Yiding, Zhao Lijie, Sun Chenxi, Liu Qinzhe, Yu Xianbin, Wang Hao, Hong Juyeong, Dai Qing, Yang Feng-Chun, Xu Mingjiang, He Chuan

Abstract excerpt

Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression1-3. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant haematopoietic stem cell self-renewal4,5. However, the open chromatin observed in TET2-deficient mouse embryonic stem cells, leukaemic cells and haematopoietic stem and progenitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39358506
DOI: 10.1038/s41586-024-07969-x
PMCID: PMC11499264

Genes

TET2
MBD6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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