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Article

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2025

Dong Zhen, Sepulveda Hugo, Arteaga-Vazquez Leo J, Blouin Chad, Fernandez Jenna, Binder Moritz, Chou Wen-Chien, Tien Hwei-Fang, Patnaik Mrinal M, Faulkner Geoffrey J, Myers Samuel A, Rao Anjana

Abstract excerpt

ASXL transcriptional regulator 1 (ASXL1) is one of the three most frequently mutated genes in age-related clonal hematopoiesis (CH), alongside DNA methyltransferase 3 alpha (DNMT3A) and Tet methylcytosine dioxygenase 2 (TET2). CH can progress to myeloid malignancies including chronic monomyelocytic leukemia (CMML) and is also strongly associated with inflammatory cardiovascular disease and all-cause mortality in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39752521
DOI: 10.1073/pnas.2413302121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.PMID 39752521Read ↗

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