Article
Positive symptoms in first-episode psychosis patients experiencing low maternal care and stressful life events: a pilot study to explore the role of the COMT gene.
Stress (Amsterdam, Netherlands) - 1 Sept 2014
Ira Elisa, De Santi Katia, Lasalvia Antonio, Bonetto Chiara, Zanatta Gioia, Cristofalo Doriana, Bertani Mariaelena, Bissoli Sarah Saviana, Riolo Rossana, Gardellin Francesco, Morandin Idana, Ramon Luana, Tansella Michele, Ruggeri Mirella, Tosato Sarah
Abstract excerpt
COMT Val(158)Met moderates the effect of stress on psychotic symptoms. Exposure to stress is also associated with mesolimbic dopamine release in individuals experiencing low maternal care. We therefore test the hypothesis that recent stressful life events are associated with more severe positive symptoms (associated with mesolimbic dopamine release) in first-episode psychosis (FEP) patients who experienced low...
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