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Article

Transposable elements and Alzheimer’s disease pathogenesis

30 Dec 2022

Abstract excerpt

Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.

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Identifiers

PMID: 36588011
DOI: 10.1016/j.tins.2022.12.003

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