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Article

Exploring and Accounting for Genetically Driven Effect Heterogeneity in Mendelian Randomization.

Genetic epidemiology - 1 Jan 2025

Jaitner Annika, Tsaneva-Atanasova Krasimira, Freathy Rachel M, Bowden Jack

Abstract excerpt

Mendelian randomization (MR) is a framework to estimate the causal effect of a modifiable health exposure, drug target or pharmaceutical intervention on a downstream outcome by using genetic variants as instrumental variables. A crucial assumption allowing estimation of the average causal effect in MR, termed homogeneity, is that the causal effect does not vary across levels of any instrument used in the...

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Identifiers

PMID: 39307953
DOI: 10.1002/gepi.22587
PMCID: PMC11656040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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