Article

The Triangulation WIthin A STudy (TWIST) framework for causal inference within Pharmacogenetic research

2021-05-07

Abstract excerpt

In this paper we review the methodological underpinnings of the general pharmacogenetic approach for uncovering genetically-driven treatment effect heterogeneity. This typically utilises only individuals who are treated and relies on fairly strong baseline assumptions to estimate what we term the ‘genetically moderated treatment effect’ (GMTE). When these assumptions are seriously violated, we show that a robust b...

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Literature Corpus work: ed7a149a-9043-59dc-bfe7-35212a0366cd
DOI: 10.1101/2021.05.04.21256612

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