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Article

Causal inference in the field of arrhythmia: An introduction to mendelian randomization.

Heart rhythm - 1 Jan 2025

Lukas Eva, van de Weijer Margot, Bergstedt Jacob, Bezzina Connie R, Treur Jorien L

Abstract excerpt

Mendelian randomization (MR) uses genetic variants associated with an exposure (eg, high blood pressure) as instrumental variables to test causal effects on an outcome (eg, atrial fibrillation [AF]). By leveraging the random assortment of genetic variants during gamete formation, MR reduces biases like confounding and reverse causation. We screened 391 papers, examining 277 that applied MR to investigate...

Topics

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Arrhythmias, Cardiac
Genetic Predisposition to Disease
Mendelian Randomization Analysis
Risk Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39019383
DOI: 10.1016/j.hrthm.2024.07.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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