Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting cellular plasticity: esculetin-driven reversion of stem cell-like characteristics and EMT phenotype in transforming cells with sequential p53/p73 knockdowns.

BMC cancer - 19 Sept 2024

Mathur Ankit, Bareja Chanchal, Mittal Milky, Singh Anjali, Saluja Daman

Abstract excerpt

The intricate interplay of cancer stem cell plasticity, along with the bidirectional transformation between epithelial-mesenchymal states, introduces further intricacy to offer insights into newer therapeutic approaches. Differentiation therapy, while successful in targeting leukemic stem cells, has shown limited overall success, with only a few promising instances. Using colon carcinoma cell strains with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Plasticity
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Epithelial-Mesenchymal Transition

Share to Gene Knockdown Techniques

Share to Neoplastic Stem Cells

Share to Tumor Protein p73

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 39300412
DOI: 10.1186/s12885-024-12736-2
PMCID: PMC11411848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting cellular plasticity: esculetin-driven reversion of stem cell-like characteristics and EMT phenotype in transforming cells with sequential p53/p73 knockdowns.PMID 39300412Read ↗

Epithelial-mesenchymal plasticity—engaging stemness in an interplay of phenotypesSemantic proximity Read ↗

Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer.Semantic proximity Read ↗

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?Semantic proximity Read ↗

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer.Semantic proximity Read ↗

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read ↗

Reprogramming to developmental plasticity in cancer stem cells.Semantic proximity Read ↗

Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancerSemantic proximity Read ↗

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.Semantic proximity Read ↗

A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells.Semantic proximity Read ↗

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signalingSemantic proximity Read ↗

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycinSemantic proximity Read ↗

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.