Article

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling

2018-05-03

Abstract excerpt

Epithelial-mesenchymal transition (EMT) and cancer stem cell formation (CSCs) are two fundamental and well-studied processes contributing to cancer metastasis and tumor relapse. Cells can undergo a partial EMT to attain a hybrid epithelial/mesenchymal (E/M) phenotype or a complete EMT to attain a mesenchymal one. Similarly, cells can reversibly gain or lose ‘stemness’. This plasticity in cell states is modulated b...

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Literature Corpus work: 3166f504-7c00-5196-8f0b-fdd1c4a672f3
DOI: 10.1101/314187

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