Article
A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells.
Cancer research - 15 Oct 2018
Koifman Gabriela, Shetzer Yoav, Eizenberger Shay, Solomon Hilla, Rotkopf Ron, Molchadsky Alina, Lonetto Giuseppe, Goldfinger Naomi, Rotter Varda
Abstract excerpt
Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer. These mutations include p53-inactivating mutations as well as oncogenic gain-of-function (GOF) mutations that endow p53 with capabilities to promote tumor progression. A primary challenge in cancer therapy is targeting stemness features and cancer stem cells (CSC) that account for tumor initiation, metastasis, and cancer...
Topics
- Animals
- Biomarkers, Tumor
- CRISPR-Cas Systems
- Carcinogenesis
- Cell Line, Tumor
- Cell Proliferation
- Embryonic Stem Cells
- Gene Expression Regulation, Neoplastic
- Humans
- Mesenchymal Stem Cells
- Mice
- Mice, Inbred C57BL
- Mutation