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Article

Autophagy unrelated transcriptional mechanisms of hydroxychloroquine resistance revealed by integrated multi-omics of evolved cancer cells.

Cell cycle (Georgetown, Tex.) - 1 Apr 2024

Vaena Silvia G, Romeo Martin J, Mina-Abouda Mirna, Funk Emma C, Fullbright George, Long David T, Delaney Joe R

Abstract excerpt

Hydroxychloroquine (HCQ) and chloroquine are repurposed drugs known to disrupt autophagy, a molecular recycling pathway essential for tumor cell survival, chemotherapeutic resistance, and stemness. We pursued a multi-omic strategy in OVCAR3 ovarian cancer and CCL218 colorectal cancer cells. Two genome-scale screens were performed. In the forward genetic screen, cell populations were passaged for 15 drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39299930
DOI: 10.1080/15384101.2024.2402191
PMCID: PMC12184169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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