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Article

ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells

5 Oct 2017

Abstract excerpt

Lysosomal autophagy inhibitors (LAI) such as hydroxychloroquine (HCQ) have significant activity in a subset of cancer cell lines. LAIs are being evaluated in cancer clinical trials, but genetic determinants of sensitivity to LAIs are unknown, making it difficult to predict which tumors would be most susceptible. Here we characterize differentially expressed genes in HCQ-sensitive (-S) and -resistant (-R) cancer...

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PMID: 28981387
DOI: 10.1080/15548627.2017.1377377

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