Article

Resolving drug effects in patient-derived cancer cells links organoid responses to genome alterations

2017-04-06

Abstract excerpt

Cancer drug screening in patient-derived cells holds great promise for personalized oncology and drug discovery but lacks standardization. Whether cells are cultured as conventional monolayer or advanced organoid cultures influences drug effects and thereby drug selection and clinical success. To precisely compare drug profiles in differently cultured primary cells, we developed DeathPro , an automated microscopy...

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Literature Corpus work: d03bc350-ce14-5aaf-92b4-c82af633b76d
DOI: 10.1101/124446

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