Article
Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Jun 2024
Cai Yaotian, Jun Gao, Zhuang Xiaojie
Abstract excerpt
It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment and a decrease in OP and fracture incidence, as well as an increase in bone mineral density (BMD) in the lumbar spine, femoral neck, and heel. Nonetheless, no significant causal effect is observed on forearm...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.