Article
Mutational spectra are associated with bacterial niche.
Nature communications - 4 Nov 2023
Ruis Christopher, Weimann Aaron, Tonkin-Hill Gerry, Pandurangan Arun Prasad, Matuszewska Marta, Murray Gemma G R, Lévesque Roger C, Blundell Tom L, Floto R Andres, Parkhill Julian
Abstract excerpt
As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur in bacterial lineages, potentially allowing decomposition analysis to detect both disruption of DNA repair processes and exposure to niche-specific mutagens. Here we reconstruct mutational spectra...
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