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Article

5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymerase.

Nucleic acids research - 16 Nov 2016

Huber Claudia, von Watzdorf Janina, Marx Andreas

Abstract excerpt

DNA methylation of cytosine in eukaryotic cells is a common epigenetic modification, which plays an important role in gene expression and thus affects various cellular processes like development and carcinogenesis. The occurrence of 5-methyl-2'-deoxycytosine (5mC) as well as the distribution pattern of this epigenetic marker were shown to be crucial for gene regulation and can serve as important biomarkers for...

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Identifiers

PMID: 27651460
DOI: 10.1093/nar/gkw812
PMCID: PMC5175357

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