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Article

Germline polygenic risk scores are associated with immune gene expression signature and immune cell infiltration in breast cancer.

American journal of human genetics - 3 Oct 2024

Liu Yuxi, Peng Cheng, Brorson Ina S, O'Mahony Denise G, Kelly Rebecca L, Heng Yujing J, Baker Gabrielle M, Grenaker Alnæs Grethe I, Bodelon Clara, Stover Daniel G, Van Allen Eliezer M, Eliassen A Heather, Kristensen Vessela N, Tamimi Rulla M, Kraft Peter

Abstract excerpt

The tumor immune microenvironment (TIME) plays key roles in tumor progression and response to immunotherapy. Previous studies have identified individual germline variants associated with differences in TIME. Here, we hypothesize that common variants associated with breast cancer risk or cancer-related traits, represented by polygenic risk scores (PRSs), may jointly influence immune features in TIME. We derived...

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Identifiers

PMID: 39270649
DOI: 10.1016/j.ajhg.2024.08.009
PMCID: PMC11480808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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