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Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

12 May 2023

Abstract excerpt

With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here, we study 1084 eQTLs affecting the TIME found through analysis of The Cancer Genome Atlas and literature curation. These TIME eQTLs are enriched in areas of active transcription, and...

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PMID: 37173324
DOI: 10.1038/s41467-023-38271-5

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