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Article

Germline Features Associated with Immune Infiltration in Solid Tumors.

Cell reports - 3 Mar 2020

Shahamatdar Sahar, He Meng Xiao, Reyna Matthew A, Gusev Alexander, AlDubayan Saud H, Van Allen Eliezer M, Ramachandran Sohini

Abstract excerpt

The immune composition of the tumor microenvironment influences response and resistance to immunotherapies. While numerous studies have identified somatic correlates of immune infiltration, germline features that associate with immune infiltrates in cancers remain incompletely characterized. We analyze seven million autosomal germline variants in the TCGA cohort and test for association with established...

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Autoimmune Diseases
DNA Repair
Germ Cells
Leukocytes
Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

T-Lymphocytes, Helper-Inducer

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Identifiers

PMID: 32130895
DOI: 10.1016/j.celrep.2020.02.039
PMCID: PMC7082123

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