Article

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

2021-04-15

Abstract excerpt

With the continued promise of immunotherapy as an avenue for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Approaches that intersect SNP modifiers of molecular phenotype, such as gene expression, with disease phenotypes have shown promise for implicating causal genetic factors. Here we ev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc712d20-8b01-5241-b34b-d9e2ada35869
DOI: 10.1101/2021.04.14.436660

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy responseDOI 10.1101/2021.04.14.436660Read

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy responseSemantic proximity Read

Association of Germline Variants in Natural Killer Cells With Tumor Immune Microenvironment Subtypes, Tumor-Infiltrating Lymphocytes, Immunotherapy Response, Clinical Outcomes, and Cancer RiskSemantic proximity Read

Machine Learning Reveals Genetic Modifiers of the Immune Microenvironment of CancerSemantic proximity Read

Inherited defects in natural killer cells shape tumor immune microenvironment, clinical outcome and immunotherapy responseSemantic proximity Read

Germline genetic contribution to the immune landscape of cancerSemantic proximity Read

Pan-cancer analysis of single-cell profiles with polygenic signals reveals genetic influences on tumor immunity across cancers.Semantic proximity Read

Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockadeSemantic proximity Read

Decoding the genetic basis of anti-tumor immunity.Semantic proximity Read

An atlas of genetic effects on cellular composition of the tumor microenvironment.Semantic proximity Read

Germline Features Associated with Immune Infiltration in Solid Tumors.Semantic proximity Read

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade.Semantic proximity Read

Pan-cancer characterization of lncRNA modifiers of immune microenvironment reveals clinically distinct de novo tumor subtypesSemantic proximity Read