Article
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver.
Cell reports - 29 Dec 2020
Wara Akm Khyrul, Wang Shijia, Wu Chun, Fang Fang, Haemmig Stefan, Weber Brittany N, Aydogan Ceren O, Tesmenitsky Yevgenia, Aliakbarian Hassan, Hawse John R, Subramaniam Malayannan, Zhao Lei, Sage Peter T, Tavakkoli Ali, Garza Amanda, Lynch Lydia, Banks Alexander S, Feinberg Mark W
Abstract excerpt
CD4+ T cells regulate inflammation and metabolism in obesity. An imbalance of CD4+ T regulatory cells (Tregs) is critical in the development of insulin resistance and diabetes. Although cytokine control of this process is well understood, transcriptional regulation is not. KLF10, a member of the Kruppel-like transcription factor family, is an emerging regulator of immune cell function. We generated...
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