Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia.

Leukemia - 1 Nov 2024

van der Ham Cédric G, Suurenbroek Lianne C, Kleisman Michelle M, Antić Željko, Lelieveld Stefan H, Yeong Marley, Westera Liset, Sonneveld Edwin, Hoogerbrugge Peter M, van der Velden Vincent H J, van Leeuwen Frank N, Kuiper Roland P

Abstract excerpt

Pediatric acute lymphoblastic leukemia (ALL) is marked by low mutational load at initial diagnosis, which increases at relapse. To determine which processes are active in (relapsed) ALL and how they behave during disease progression before and after therapy, we performed whole genome sequencing on 97 tumor samples of 29 multiply relapsed ALL patients. Mutational load increased upon relapse in 28 patients and upon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Neoplasm Recurrence, Local

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Reactive Oxygen Species

Share to Recurrence

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39232206
DOI: 10.1038/s41375-024-02403-7
PMCID: PMC11518985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia.PMID 39232206Read ↗

Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.Semantic proximity Read ↗

Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.Semantic proximity Read ↗

Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Mutational dynamics of early and late relapsed childhood ALL: rapid clonal expansion and long-term dormancy.Semantic proximity Read ↗

Acquired thiopurine resistance and mismatch repair aberrations in paediatric B-cell acute lymphoblastic leukaemia relapse: A real-world data integrating mutational signatures, clones and clinical thiopurine dosing patterns.Semantic proximity Read ↗

The evolution of relapse of adult T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.Semantic proximity Read ↗

Investigating the causes of childhood acute lymphoblastic leukemia through mutational epidemiology.Semantic proximity Read ↗

Deciphering the Clonal Origin of Relapsed Acute Lymphoblastic Leukemia in Children.Semantic proximity Read ↗

Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.