Article
Acquired thiopurine resistance and mismatch repair aberrations in paediatric B-cell acute lymphoblastic leukaemia relapse: A real-world data integrating mutational signatures, clones and clinical thiopurine dosing patterns.
British journal of haematology - 1 Jul 2026
Bhatia Prateek, Sharun Sharun, Palla Swetha, Brady Samuel W, Kirubanandhan Sangeetha, Ansari Sada, Singh Minu, Sreedharanunni Sreejesh, Das Anirban, Trehan Amita
Abstract excerpt
Acquired thiopurine resistance and mismatch repair (MMR) deficiency are increasingly recognised drivers of relapse in paediatric B-cell acute lymphoblastic leukaemia (B-ALL); however, their real-world genomic prevalence and link to maintenance dosing patterns remain poorly characterised. Paediatric B-ALL relapse cases (2018-2024) were subjected to whole exome sequencing (WES; 200-250× depth; n = 70) and deep...
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