Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.

doi:10.1182/bloodadvances.2019000051

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Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.

Blood advances - 22 Oct 2019

Hoell Jessica I, Ginzel Sebastian, Kuhlen Michaela, Kloetgen Andreas, Gombert Michael, Fischer Ute, Hein Daniel, Demir Salih, Stanulla Martin, Schrappe Martin, Zur Stadt Udo, Bader Peter, Babor Florian, Schuster Friedhelm, Strahm Brigitte, Alten Julia, Moericke Anja, Escherich Gabriele, von Stackelberg Arend, Thiele Ralf, McHardy Alice C, Peters Christina, Bornhauser Beat, Bourquin Jean-Pierre, Krause Stefan, Enczmann Juergen, Meyer Lüder Hinrich, Eckert Cornelia, Borkhardt Arndt, Meisel Roland

Abstract excerpt

Survival of patients with pediatric acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-SCT) is mainly compromised by leukemia relapse, carrying dismal prognosis. As novel individualized therapeutic approaches are urgently needed, we performed whole-exome sequencing of leukemic blasts of 10 children with post-allo-SCT relapses with the aim of thoroughly characterizing...

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Identifiers

PMID: 31648313
DOI: 10.1182/bloodadvances.2019000051
PMCID: PMC6849953

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Source receipt: pubmed, retrieved 6 Sept 2026.

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