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Article

The evolution of relapse of adult T cell acute lymphoblastic leukemia.

Genome biology - 23 Nov 2020

Sentís Inés, Gonzalez Santiago, Genescà Eulalia, García-Hernández Violeta, Muiños Ferran, Gonzalez Celia, López-Arribillaga Erika, Gonzalez Jessica, Fernandez-Ibarrondo Lierni, Mularoni Loris, Espinosa Lluís, Bellosillo Beatriz, Ribera Josep-Maria, Bigas Anna, Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

BACKGROUND: Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been less studied than its cognate pediatric malignancy, which is more prevalent. A higher percentage of the adult patients relapse, compared to children. It is thus essential to study the mechanisms of relapse of adult T-ALL cases. RESULTS: We profile whole-genome somatic...

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Identifiers

PMID: 33225950
DOI: 10.1186/s13059-020-02192-z
PMCID: PMC7682094

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