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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency

4 Sept 2024

Abstract excerpt

As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related prokaryotic endonucleases have been identified. However, as these bacterial enzymes are not naturally present in mammalian cells, whether and how bacterial Cas9 proteins are recognized and regulated by mammalian...

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PMID: 39228373
DOI: 10.1093/nar/gkae761

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