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Article

Engineering Cas9: next generation of genomic editors.

Applied microbiology and biotechnology - 14 Feb 2024

Kovalev Maxim A, Davletshin Artem I, Karpov Dmitry S

Abstract excerpt

The Cas9 endonuclease of the CRISPR/Cas type IIA system from Streptococcus pyogenes is the heart of genome editing technology that can be used to treat human genetic and viral diseases. Despite its large size and other drawbacks, S. pyogenes Cas9 remains the most widely used genome editor. A vast amount of research is aimed at improving Cas9 as a promising genetic therapy. Strategies include directed evolution of...

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Identifiers

PMID: 38353732
DOI: 10.1007/s00253-024-13056-y
PMCID: PMC10866799

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