Article
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
Nature - 30 Jul 2015
McKinney Eoin F, Lee James C, Jayne David R W, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion inhibits the immune response, facilitating viral persistence. Here we show that a transcriptional...
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