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CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

14 Jun 2021

Abstract excerpt

In chronic infections and in cancer, persistent antigen stimulation under suboptimal conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are characterized by an increased expression of inhibitory markers and a progressive and hierarchical loss of function. Although cancer-induced exhaustion in CD8 T cells has been well-characterized and identified as a therapeutic target (i.e., via...

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PMID: 34127507
DOI: 10.1158/1078-0432.ccr-21-0206

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