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Genome-wide analysis identifies novel shared loci between depression and white matter microstructure.

Molecular psychiatry - 1 Aug 2025

Zhao Qiyu, Wang Shuo, Xiong Di, Liu Mengge, Zhang Yujie, Zhao Guoshu, Zhao Jiaxuan, Shi Ziqing, Zhang Zhihui, Lei Minghuan, Zhai Ying, Xu Jinglei, Hao Xiaoke, Li Shen, Liu Feng

Abstract excerpt

Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic basis remains largely unclear. Utilizing the largest available genome-wide association study (GWAS) datasets for depression (N = 674,452) and white matter microstructure (N = 33,224), assessed through diffusion tensor imaging metrics such as fractional anisotropy (FA)...

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PMID: 39972055
DOI: 10.1038/s41380-025-02932-2
PMCID: PMC12240862

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