Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis identifies novel shared loci between depression and white matter microstructure

19 Feb 2025

Abstract excerpt

Depression, a complex and heritable psychiatric disorder, is associated with alterations in white matter microstructure, yet their shared genetic basis remains largely unclear. Utilizing the largest available genome-wide association study (GWAS) datasets for depression (N = 674,452) and white matter microstructure (N = 33,224), assessed through diffusion tensor imaging metrics such as fractional anisotropy (FA)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Neuroimaging Techniques and Applications
Share to RNA regulation and disease
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39972055
DOI: 10.1038/s41380-025-02932-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis identifies novel shared loci between depression and white matter microstructurePMID 39972055Read ↗

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.Semantic proximity Read ↗

Shared Genetic Underpinnings of Gray Matter Volume Alterations and Metabolic Traits in Major Depressive DisorderSemantic proximity Read ↗

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbiditiesSemantic proximity Read ↗

Investigating the shared genetic architecture between depression and subcortical volumes.Semantic proximity Read ↗

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Semantic proximity Read ↗

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Semantic proximity Read ↗

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.Semantic proximity Read ↗

Mapping heterogeneity in the neuroanatomical correlates of depressionSemantic proximity Read ↗

Common genetic variation influencing human white matter microstructureSemantic proximity Read ↗

Multilayer Genomic Characterization of a Shared Genetic Factor Linking Depression-Related Liability and Reduced Physical Function.Semantic proximity Read ↗

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.Semantic proximity Read ↗

A joint study of whole exome sequencing and structural MRI analysis in major depressive disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.