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Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain

5 Jul 2021

Abstract excerpt

Background: Alzheimer’s disease (AD) and depression are debilitating brain disorders that are often comorbid. Shared brain mechanisms have been implicated, yet findings are inconsistent, reflecting the complexity of the underlying pathophysiology. As both disorders are (partly) heritable, characterising their genetic overlap may provide aetiological clues. While previous studies have indicated negligible genetic...

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PMID: 34290577
DOI: 10.3389/fnins.2021.653130

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