Article
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
Human molecular genetics - 1 Dec 2010
Cha Pei-Chieng, Mushiroda Taisei, Takahashi Atsushi, Kubo Michiaki, Minami Shiro, Kamatani Naoyuki, Nakamura Yusuke
Abstract excerpt
Warfarin is a commonly used anticoagulant, whose dose needs to be determined for each individual patient owing to large inter-individual variability in its therapeutic dose. Although several clinical and genetic variables influencing warfarin dose have been identified, uncovering additional factors are critically important for safer use of warfarin. Through a genome-wide association study, we identified...
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