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Article

Impact of genetic factors (CYP2C9, VKORC1 and CYP4F2) on warfarin dose requirement in the Turkish population.

Basic & clinical pharmacology & toxicology - 1 Mar 2013

Özer Mahmut, Demirci Yeliz, Hizel Candan, Sarikaya Sabit, Karalti İskender, Kaspar Çiğdem, Alpan Serdar, Genç Ece

Abstract excerpt

Warfarin has a narrow therapeutic index and displays marked person-to-person variation in dose requirement. Functional polymorphisms at candidate genes can therefore offer utility as biomarkers to individualize warfarin treatment. The main objective of this study was to determine whether and to what extent variability in warfarin dose requirements was determined by polymorphisms in CYP2C9, VKORC1, CYP4F2...

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Source

Identifiers

PMID: 23061746
DOI: 10.1111/bcpt.12024

Genes

VKORC1
EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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