Article
Genetic factors contribute to patient-specific warfarin dose for Han Chinese.
Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2008
Wang Ting-Liang, Li Hong-Lei, Tjong Wen-Ye, Chen Qian-Su, Wu Guan-Sheng, Zhu Hai-Tao, Hou Zi-Shan, Xu Shu, Ma Sheng-Jun, Wu Madeline, Tai Susan
Abstract excerpt
BACKGROUND: Warfarin is a commonly prescribed anticoagulant drug for the prevention of thromboses. To address the association of genetic factors and warfarin dosage for ethnic Han Chinese, we genotyped six candidate genes involved in the warfarin interactive pathway with focus on SNPs with reported association with warfarin dose. METHODS: We recruited a study population consisted of 318 patients receiving...
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