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Article

An additional proofreader contributes to DNA replication fidelity in mycobacteria.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2024

Deng Ming-Zhi, Liu Qingyun, Cui Shu-Jun, Wang Yi-Xin, Zhu Guoliang, Fu Han, Gan Mingyu, Xu Yuan-Yuan, Cai Xia, Wang Sheng, Sha Wei, Zhao Guo-Ping, Fortune Sarah M, Lyu Liang-Dong

Abstract excerpt

The removal of mis-incorporated nucleotides by proofreading activity ensures DNA replication fidelity. Whereas the ε-exonuclease DnaQ is a well-established proofreader in the model organism Escherichia coli, it has been shown that proofreading in a majority of bacteria relies on the polymerase and histidinol phosphatase (PHP) domain of replicative polymerase, despite the presence of a DnaQ homolog that is...

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Share to Antibiotic Resistance in Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39141351
DOI: 10.1073/pnas.2322938121
PMCID: PMC11348249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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