Article

Mycobacterial DnaQ is an Alternative Proofreader Ensuring DNA Replication Fidelity

2023-10-26

Abstract excerpt

Remove of mis-incorporated nucleotides ensures replicative fidelity. Although the ε-exonuclease DnaQ is a well-established proofreader in the model organism Escherichia coli , proofreading in mycobacteria relies on the polymerase and histidinol phosphatase (PHP) domain of replicative polymerase despite the presence of an alternative DnaQ homolog. Here, we show that depletion of DnaQ in Mycolicibacterium smegmati...

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Literature Corpus work: b23a3f3c-faa4-5328-ab04-94e323a5ffe3
DOI: 10.1101/2023.10.24.563508

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