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Article

The unique role of nucS-mediated noncanonical mismatch repair in Mycobacterium tuberculosis resistance evolution.

mBio - 11 Feb 2026

Martín-Blecua Isabel, Sastre-Domínguez Jorge, Valverde José Ramón, García-Bravo Pablo, Ruiz-Enamorado Ángel, Prados-Rosales Rafael, Das Lahari, Jacobs William R, San Millán Álvaro, Blázquez Jesús, Gullón Sonia

Abstract excerpt

DNA surveillance mechanisms are crucial for maintaining genome stability and minimizing mutation rates. Mismatch repair (MMR) corrects replication errors that escape DNA-polymerase proofreading. In most organisms, MMR is orchestrated by MutS and MutL proteins. However, certain Archaea and Actinobacteria, including the major human pathogen Mycobacterium tuberculosis, lack these components. Instead, they appear to...

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Identifiers

PMID: 41427728
DOI: 10.1128/mbio.03310-25
PMCID: PMC12892979

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