Article
A distinct role of formamidopyrimidine DNA glycosylase (MutM) in down-regulation of accumulation of G, C mutations and protection against oxidative stress in mycobacteria.
DNA repair - 1 Dec 2007
Jain Ruchi, Kumar Pradeep, Varshney Umesh
Abstract excerpt
Reactive oxygen species produced as a part of cellular metabolism or environmental agent cause a multitude of damages in cell. Oxidative damages to DNA or the free nucleotide pool result in occurrence of 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA, and failure to replace it with the correct base results in a variety of mutations in the genome. Formamidopyrimidine DNA glycosylase (Fpg/MutM), a functionally conserved...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.