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Article

Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.

Diabetologia - 1 Apr 2015

Kim Yong Kyung, Joung Kyong Hye, Ryu Min Jeong, Kim Soung Jung, Kim Hyeongseok, Chung Hyo Kyun, Lee Min Hee, Lee Seong Eun, Choi Min Jeong, Chang Joon Young, Hong Hyun Jung, Kim Koon Soon, Lee Sang-Hee, Kweon Gi Ryang, Kim Hail, Lee Chul-Ho, Kim Hyun Jin, Shong Minho

Abstract excerpt

AIM/HYPOTHESIS: Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS: We examined the in vivo phenotypes of beta cell dysfunction in beta cell-specific Crif1 (also...

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PMID: 25660120
DOI: 10.1007/s00125-015-3506-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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