Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.

doi:10.1073/pnas.1032913100

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Article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003

Patti Mary Elizabeth, Butte Atul J, Crunkhorn Sarah, Cusi Kenneth, Berria Rachele, Kashyap Sangeeta, Miyazaki Yoshinori, Kohane Isaac, Costello Maura, Saccone Robert, Landaker Edwin J, Goldfine Allison B, Mun Edward, DeFronzo Ralph, Finlayson Jean, Kahn C Ronald, Mandarino Lawrence J

Abstract excerpt

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible...

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Identifiers

PMID: 12832613
DOI: 10.1073/pnas.1032913100
PMCID: PMC166252

Genes

NRF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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