Article

Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting Proliferation

2021-03-06

Abstract excerpt

<h4>SUMMARY</h4> Finding therapies that can protect and expand functional β-cell mass is a major goal of diabetes research. Here we generated β-cell-specific conditional knockout and gain-of-function mouse models and used human islet transplant experiments to examine how manipulating Nrf2 levels affects β-cell survival, proliferation and mass. Depletion of Nrf2 in β-cells resulted in decreased glucose-stimulated...

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Literature Corpus work: 706dd15a-0163-55d3-b208-ccf576ecdc18
DOI: 10.1101/2021.03.05.434145

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