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Article

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.

The Journal of biological chemistry - 23 Jul 2004

Gauthier Benoit R, Brun Thierry, Sarret Eve Julie, Ishihara Hisamitsu, Schaad Olivier, Descombes Patrick, Wollheim Claes B

Abstract excerpt

Mutations in the transcription factor IPF1/PDX1 have been associated with type 2 diabetes. To elucidate beta-cell dysfunction, PDX1 was suppressed by transduction of rat islets with an adenoviral construct encoding a dominant negative form of PDX1. After 2 days, there was a marked inhibition of insulin secretion in response to glucose, leucine, and arginine. Increasing cAMP levels with forskolin and...

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Source

Identifiers

PMID: 15151993
DOI: 10.1074/jbc.M405030200

Genes

PDX1
TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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