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Article

pyTWMR: transcriptome-wide Mendelian randomization in python.

Bioinformatics (Oxford, England) - 2 Aug 2024

Oreshkov Sergey, Lepik Kaido, Santoni Federico

Abstract excerpt

MOTIVATION: Mendelian randomization (MR) is a widely used approach to estimate causal effect of variation in gene expression on complex traits. Among several MR-based algorithms, transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) enables the uses of multiple SNPs as instruments and multiple gene expression traits as exposures to facilitate causal inference in observational...

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PMID: 39128017
DOI: 10.1093/bioinformatics/btae505
PMCID: PMC11341121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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