Article

Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseases

2020-11-10

Abstract excerpt

Isolating causal genes from enormous genome-wide association signals of complex phenotypes remains an open and challenging question. SMR (Summary-based Mendelian Randomization) is a widely used Mendelian randomization (MR) method for inferring causal genes by using a single expression quantitative trait locus (eQTL). In the present study, we explored more powerful MR methods based on multiple eQTLs. Among six repr...

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Literature Corpus work: 24d1eb42-0c52-5be5-aec6-c8380edf66de
DOI: 10.1101/2020.11.09.374298

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