Article
Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies.
Nature communications - 31 Jul 2020
Yuan Zhongshang, Zhu Huanhuan, Zeng Ping, Yang Sheng, Sun Shiquan, Yang Can, Liu Jin, Zhou Xiang
Abstract excerpt
Integrating results from genome-wide association studies (GWASs) and gene expression studies through transcriptome-wide association study (TWAS) has the potential to shed light on the causal molecular mechanisms underlying disease etiology. Here, we present a probabilistic Mendelian randomization (MR) method, PMR-Egger, for TWAS applications. PMR-Egger relies on a MR likelihood framework that unifies many...
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