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Article

The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response.

Journal of translational medicine - 9 Aug 2024

Sæterstad Siri, Østvik Ann Elisabeth, Hansen Marianne Doré, Bruland Torunn, van Beelen Granlund Atle

Abstract excerpt

BACKGROUND: ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD). The lack of an ERAP2 gene homologue in mice has hampered functional studies, and most human studies have focused on cells of hematopoietic origin. Using an IBD biobank as vantage point, this study explores how genetic...

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Topics

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Share to Aminopeptidases
Share to Colon
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Inflammatory Bowel Diseases

Share to Intestinal Mucosa

Share to Minor Histocompatibility Antigens

Share to Organoids

Source

Open in PubMed Open full text

Identifiers

PMID: 39123229
DOI: 10.1186/s12967-024-05532-w
PMCID: PMC11316291

Genes

ERAP2
ANPEP
AOC1
CPE
FGL2
FLNA
GDF15
HMCN2
LGALS3
MDK
MEP1A
MUC17
SLC40A1
SLC5A1
TNFSF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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