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Article

Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease.

Mammalian genome : official journal of the International Mammalian Genome Society - 22 Dec 2025

Win Lynn K, Cheng Guo, Ashton James J, Kadhim Alex Z, Green Zachary, Beattie R Mark, Ennis Sarah

Abstract excerpt

Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally impactful variants present in ERAP1 and ERAP2 in 2 cohorts of patients diagnosed with inflammatory bowel disease (IBD; Crohn's disease (CD) or ulcerative colitis (UC)). We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41428259
DOI: 10.1007/s00335-025-10183-3
PMCID: PMC12722269

Genes

ERAP2
ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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