Article
ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population.
Innate immunity - 1 Jul 2017
Castro-Santos Patricia, Moro-García Marco Antonio, Marcos-Fernández Raquel, Alonso-Arias Rebeca, Díaz-Peña Roberto
Abstract excerpt
Large genome-wide analysis studies (GWAS) and meta-analyses have dramatically increased our knowledge of the genetic risk factors of inflammatory bowel disease (IBD), identifying at least 163 loci. The endoplasmic reticulum aminopeptidase-2 ( ERAP2) gene has been reported as a potential candidate gene for IBD. GWAS have also shown the potential associations between ERAP single nucleotide polymorphisms (SNP) loci...
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