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Article

A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci.

The Journal of allergy and clinical immunology - 1 Mar 2022

Chang Xiao, March Michael, Mentch Frank, Nguyen Kenny, Glessner Joseph, Qu Huiqi, Liu Yichuan, Furuta Glen, Aceves Seema, Gonsalves Nirmala, Nadeau Kari, Cianferoni Antonella, Spergel Jonathan, Sleiman Patrick, Hakonarson Hakon

Abstract excerpt

BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus marked by eosinophilic infiltration. Cumulative evidence indicates that the risk of EoE involves the complex interplay of both genetic and environmental factors. Because only a few genetic loci have been identified in EoE, the genetic underpinning of EoE remains largely elusive. OBJECTIVE: We sought to identify genetic...

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Identifiers

PMID: 34506852
DOI: 10.1016/j.jaci.2021.08.018
PMCID: PMC9579995

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